An acerbic, crippled diagnostician who is addicted to painkillers solves impossible medical cases while clashing with friends and colleagues.

Dr. Gregory House is devoid of bedside manner and wouldn't even talk to his patients if he could get away with it. Dealing with his own constant physical pain and ignoring his pain killing addiction, he uses his cane to punctuate his acerbic, brutally honest demeanor. House and his team deal with unusual medical mysteries.

"An ex-Marine haunted by a tragic past, Tommy Riordan returns home and enlists his father, a recovering alcoholic and his former coach, to train him for an MMA tournament awarding the biggest purse in the history of the sport. Tommy's estranged brother Brendan, a former MMA fighter unable to provide for his family as a public school teacher, also enters the competition. Set on a collision course with each other, the two brothers must finally confront...

Soon after Emma and Hook unwittingly bring Elsa of Arendelle to Storybrooke, they encounter the mysterious "Snow Queen," whose relentless obsession with both Emma and Elsa has chilling consequences. Meanwhile, it appears Regina has at last found true love with Robin Hood, but how will she react when her happy ending is thwarted yet again by a maddening, seemingly pre-ordained twist of fate?

After Regina crushes the heart of her Dark Half, it appears Storybrooke will finally enjoy an era of tranquility. But this reprieve is short-lived when the Evil Queen reemerges and wreaks a level of havoc and terror that makes her previous cruelties pale by comparison. Desperate to right her counterpart's wrongs, Regina fights the ultimate battle against her nemesis, but can one survive if the other is destroyed?

On her 28th birthday, Emma Swan meets Henry, the son she gave up for adoption 10 years ago. Henry believes Emma is the daughter of Snow White and Prince Charming, prophesied to break a powerful curse. Unconvinced, Emma returns Henry to Storybrooke, where she encounters the enigmatic Mr. Gold and clashes with mayor Regina Mills, the boy's adoptive mother, who Henry insists is none other than the Evil Queen!

Dr. Gregory House and his hand-picked team of young medical experts will do whatever it takes to solve the puzzles that other doctors give up on.

Dr. Gregory House still has the most unapologetically prickly bedside manner ever, but his genius for solving the medical mysteries other practitioners can't has earned him the respect of his team. House's unpredictable cases, from killer germs to killer secrets, strain his already tenuous relationship with his co-workers and put his own health at risk.