Presents the first five years' worth of "Locas" stories, in chronological order. Includes "Mechan-X," the very first Maggie and Hopey story; the full-length graphic novel "Las Mujeres Perdidas" (co-starring wrestling legend Rena Titañon); and two dozen other classic stories.

Treats the history of comic books and displays one story by each of 22 artists: William M. Gaines, Will Eisner, Jack Kirby, Al Feldstein, Harvey Kurtzman, Stan Lee, Robert Crumb, Victor Moscoso, Spain, Gilbert Shelton, Dan O'Neill, Shary Feinniken, Bill Griffith, Harvey Pekar, Jamie Hernandez, Lynda Barry, Paul Mavrides, Francoise Mouly, Charles Burns, Sue Coe, Art Spiegelman, and Frank Miller.

Reprints of comics written and drawn by Gilbert Hernandez between 1982 and 2003, tracing the lives of the residents of the mythical Latin American village from the arrival of Luba, the guiding material spirit of Palomar, to her departure twenty years later.