They come together by chance in the heart of New York City, four young women at turning points in their lives. Claire Kelly finds the walk-up apartment -- a spacious loft in Hell's Kitchen. But the aspiring shoe designer needs at least one roommate to manage it. She meets Abby Williams, a writer trying to make it on her own, far away from her successful family in L.A. Four years later, Morgan Shelby joins them. She's ambitious, with a serious finance job on Wall Street. Then Sasha Hartman, a medical student whose identical twin sister is a headline-grabbing supermodel. And so the sprawling space, with its exposed brick and rich natural light, becomes a home to friends about to embark on new, exhilarating adventures. Frustrated by her ultra-conservative boss, Claire soon faces a career crisis as a designer. Abby is under the spell of an older man, an off-off-Broadway producer who exploits her and detours her from her true talent as a novelist, while destroying her self-confidence. Morgan is happily in love with a successful restaurateur who supplies her roommates with fine food. At her office, she begins to suspect something is off about her boss, a legendary investment manager whom she's always admired. But does she even know him? And Sasha begins an all-work-no-play residency as an OB/GYN, as her glamorous jet-set sister makes increasingly risky decisions.