Lie Down with Dogs is the story of two people caught up in events they can neither understand nor control. Successful Chicago businessman Robert Cooper dislikes inconvenience, challenges to his authority, and dogs, but he must deal with all of these and more when he befriends a small boy late at night on a desolate country road and is thrown into uneasy partnership with the boy's caretaker, Lisa Jacobi, and her enormous Bernese Mountain Dog. Cooper and the independent Lisa have just one thing in common: the protection of young Luke from the people who are after him. And the two have almost no knowledge of who could be after the boy or why. What Lisa does know is that Luke's widowed father, Carl McCain, an old college friend, brought the boy to her rural cabin and begged her to keep Luke till he returned. Then Carl disappeared. When the hard-eyed men show up, Lisa and Cooper's flight begins. Together they search desperately for the source of the danger threatening the boy. In the process they discover evidence of a well-organized conspiracy and - as their reluctant partnership stirs emotions they have protected for too long - of unexpected things about themselves.