Rebecca Jean Wooten St. Clair and her sister, Carleen, pack up their two teenage daughters and leave California via Route 66 for Blue Lick Springs, Kentucky, where they will celebrate the seventy-fifth birthday of their mother, Lila Mae. Waiting for them is their sibling Irene ("Baby Sister"); Olive, their feisty, ninety-five-year-old grandmother; and a hometown thats troubled by a string of mysterious crimes, and invaded by Horace Castle, a slick-talking real estate developer. Rebecca, Irene, and Olive join forces with their zany friends and relatives to save Blue Lick Springs while each sister grapples to rescue her own heart.