Growing up can be a bumpy road, and it's no exception for Riley, who is uprooted from her Midwest life when her father starts a new job in San Francisco. Like all of us, Riley is guided by her emotions ; Joy, Fear, Anger, Disgust, and Sadness. The emotions live in Headquarters, the control center inside Riley's mind, where they help advise her through everyday life.

Woody has always been confident about his place in the world and that his priority is taking care of his kid, whether that's Andy or Bonnie. But when Bonnie adds a reluctant new toy called 'Forky' to her room, a road trip adventure alongside old and new friends will show Woody how big the world can be for a toy.