While Captain Chakotay and the U.S.S. Voyager set course for a region of the Delta Quadrant far beyond anything previously explored, Vice Admiral Kathryn Janeway, who recently endured a great trauma, is recalled to the Alpha Quadrant where she must be re-evaluated for her next mission.

Johnny Smith's life is interrupted by a near fatal car crash that leaves him in a deep coma for six years. When he regains consciousness, he discovers that he now possesses amazing psychic powers that allow him to see into the lives of anyone he touches.

Johnny Smith faces the greatest challenges of his psychically altered existence in this final season.

In season four, Captain Janeway and her crew continue on their journey through space beginning with the conclusion of their encounter with the Borg in "Scorpion, Part Two." Heroism is a major theme throughout the season and the crew demonstrates this quality best in "Nemesis" and "Scientific Method." The dangerous nature of space travel is also highlighted in "Hunters" and "Prey."